Functional significance of serotonin receptor dimerization
نویسندگان
چکیده
منابع مشابه
The Functional Significance of G Protein-coupled Receptor Dimerization
THE FUNCTIONAL SIGNIFICANCE OF G PROTEIN-COUPLED RECEPTOR DIMERIZATION by Matthew R. Whorton Chair: Roger K. Sunahara G protein-coupled receptors (GPCRs) are seven transmembrane domain proteins that transduce a diverse array extracellular signals across the plasma membrane and couple to the heterotrimeric family of G proteins. Like most intrinsic membrane proteins, GPCRs are capable of oligomer...
متن کاملG-protein Coupled Receptor Dimerization
A growing body of evidence suggests that GPCRs exist and function as dimers or higher oligomers. The evidence for GPCR dimerization comes from biochemical, biophysical and functional studies. In addition, researchers have shown the occurrence of heterodimerization between different members of the GPCR family. Two receptors can interact with each other to make a dimer through their extracellular...
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متن کاملFluorescence correlation spectroscopy analysis of serotonin, adrenergic, muscarinic, and dopamine receptor dimerization: the oligomer number puzzle.
The issue of G protein-coupled receptor (GPCR) oligomer status has not been resolved. Although many studies have provided evidence in favor of receptor-receptor interactions, there is no consensus as to the exact oligomer size of class A GPCRs. Previous studies have reported monomers, dimers, tetramers, and higher-order oligomers. In the present study, this issue was examined using fluorescence...
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ژورنال
عنوان ژورنال: Experimental Brain Research
سال: 2013
ISSN: 0014-4819,1432-1106
DOI: 10.1007/s00221-013-3622-1